MDR1

Many herding dog breeds are afflicted with a mutation of the multi-drug resistance (MDR1) gene. This gene encodes a protein (P-glycoprotein) that is responsible for removing certain drugs and toxins from the brain. Dogs that carry the MDR1 genetic defect cannot rid their brains of the problem drugs. The result is a neurotoxic buildup that can cause abnormal neurological symptoms and/or death.  

Breeds known to carry the MDR1 mutation include Australian Shepherds of all sizes, Collies, English Shepherds, Longhaired Whippets, McNabs, Old English Sheepdogs, Shetland Sheepdogs, and Silken Windhounds.  Research has shown that every three of every four Collies and two of every four Australian Shepherds (of any size) have at least one copy of the mutated gene.  This also means that if your mixed breed dog has, or you think s/he might have, any of these breeds in its pedigree, you should test your dog and avoid the drugs on the list until you have test results.

A simple check swab test or a blood test is available to screen for the presence of the mutated MDR1 gene. Test results indicate if the dog carries two, one or no copies of the mutated gene. For further information on the MDR 1 genetic mutation and the test, visit the website of the Veterinary Clinical Pharmacology Laboratory at Washington State University's College of Veterinary Medicine at vcpl.vetmed.wsu.edu/.

Download and print the MDR1 Problem Drug Info Sheet

Give a copy to your vet for your dog's medical records, and carry a copy in your car.

MDR1 Tags

Don't take a chance with the health of your dog.  An MDR1 collar hang tag can help protect your dog from receiving problem drugs.  You can order them at our e-shop, MDR1 Tag Order Form.

www.busteralert.org

The busteralert.org website is being revised. The basic information is available at https://busteralert.webnode.com/.

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Contact

Mini Aussie Rescue & Support, Inc. Mini Aussie Rescue & Support
PO Box 636
Hillsboro, NH 03244

Please click on the Contact Tab to find your local MARS contact person.
MARS Lost Dog Hotline -
for EMERGENCIES only.
1-877-405-MARS
(1-877-405-6277)

This phone number is only to be used for reporting MARS dogs that are missing or lost.

Please use the email addresses on the Contacts page for any other inquiry. We appreciate you honoring this request.